Holebas suffered a hamstring injury during the FA Cup semi-final win over Wolves, Quina has a shoulder injury and Cleverley a calf problem.
Arsenal’s Sokratis Papastathopoulos begins a two-match ban for accumulating10 bookings.
Granit Xhaka has a groin injury and will be assessed ahead of the game,while Danny Welbeck, Rob Holding and Hector Bellerin remained sidelined.
Watford manager JaviGracia says the FA Cup final won’t be a distraction:“I am only thinking about trying to win the next game. I don’t want tothink any further.
“We have good professionals and, with these players, it is easy as theyknow the next game is very important.
“We don’t have only one final – we have seven finals. All of them arefocused on the next game.”
Arsenal head coach Unai Emery: “Each match gives us a bigchallenge for the possibility to improve and take three points and thepossibility to end the season in the top four.
“For us that would be a big success. When we started last in the tableafter the first two matches in the season we were thinking about arriving inthis moment with the possibility of being in the top four in our hands.”